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Alpha-Keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells
Carcinogenesis, 07/31/09
Nian H et al. – The studies confirm that in addition to targeting redox–sensitive signaling molecules, alpha–keto acid metabolites of organoselenium compounds alter HDAC activity and histone acetylation status in colon cancer cells, as recently observed in human prostate cancer cells.
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