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Insulin-like growth factor-I receptor blockade reduces the invasiveness of gastrointestinal cancers via blocking production of matrilysin
Carcinogenesis, 07/31/09
Adachi Y et al. – Blockade of IGF–IR is involved in the suppression of cancer cell invasion through downregulation of matrilysin. Strategies of targeting IGF–IR may have significant therapeutic utility to prevent invasion and progression of human GI carcinomas.
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