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Origin and fate of blood cells deficient in glycosylphosphatidylinositol-anchored protein among patients with bone marrow failure
British Journal of Haematology, 07/30/09
Sugimori C et al. – The findings suggest that the PNH–type cells in patients with BM failure are derived from single PIGA mutant haematopoietic stem cells even when their percentages are <1% and their fate depends on the proliferation and self–maintenance properties of the individual PIGA mutants.
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