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See Latest ArticlesA Phase IB Trial of Intravenous INO-1001 Plus Oral Temozolomide in Subjects with Unresectable Stage-III or IV Melanoma
Cancer Investigation, 07/29/09
Bedikian AY et al. – INO–1001 at doses of 100, 200 and 400 mg was given intravenous for 1 hr q 12 hr for 10 doses. INO–1001 had a moderate clearance, volume of distribution and a relatively short terminal half–life. Myelosuppression and elevation of liver transaminases were dose–limiting toxicities (DLTs) of INO–1001 at 400 mg.
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