Oncology Medical News about Gliomas, Pediatric, Therapy

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Paediatric high and low grade glioma: The impact of tumour biology on current and future therapy
British Journal of Neurosurgery, 08/03/09

Hargrave D – Review discusses the current therapies available for pediatric brain tumors, and highlights the need of targeted therapies. Main points of discussion are:

Most common type of paediatric brain tumour range from benign low grade gliomas to aggressive brainstem gliomas
Current therapies: neurosurgery, radiotherapy, chemotherapy or combination of three

Increasing knowledge of glioma biology is starting to impact on drug development towards targeted therapies:

An activated BRAF/MAPK/ERK pathway in the majority of cases of pilocytic astrocytoma is reported
Targeted therapies against VEGFR are already playing a role in the management of glioblastoma
It is likely that high grade gliomas in children and adults share common aberrant molecular pathways
Selection for specific targeted therapy will require individual case by case testing for target presence to maximise the efficacy of molecular therapy

A new era of molecular based therapies offers the promise of major benefits in the management of paediatric glioma but translating this promise into reality will require further understanding of the biology driving these tumours.

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What's New in Alternative Therapies for Asthmatic Children
Journal of Community Health Nursing, 11/06/09 Relevance Score: 69%

Pediatric psoriasis: an update
Therapeutics and Clinical Risk Management, 10/22/09 Relevance Score: 69%

Treatment of recurrent high-grade gliomas
Current Opinion in Neurology, 11/12/09 Relevance Score: 68%

Pediatric Asthma: An Integrative Approach to Care
Nutrition in Clinical Practice, 10/23/09 Relevance Score: 68%

Outcome and prognostic features in pediatric gliomas
Cancer, 10/12/09 Relevance Score: 68%