Oncology Medical News about Sickle Cell Anemia, Stroke

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Stroke in Sickle Cell Anemia: Alternative Etiologies
Pediatric Neurology , 08/06/09

Dowling MM et al. – An 11–year–old girl with sickle cell anemia presented with severe headache and was found to have recurrent bilateral multifocal strokes in a cardioembolic pattern. Evaluation revealed the presence of a patent foramen ovale, antiphospholipid antibodies, and elevations in factor VIII and lipoprotein(a). Sickle cell anemia is itself a hypercoagulable state with potential for increased right heart pressures, both of which predispose to paradoxical embolization via right–to–left intracardiac shunting of emboli, thus causing stroke.

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Study Targets Stroke Prevention in Children With Sickle Cell Anemia
Internet Source, 10/30/09 Relevance Score: 88%

Sickle cell disease and stroke
Blood, 10/13/09 Relevance Score: 88%

Transcranial doppler ultrasonography (TCD) in infants with sickle cell anemia: Baseline data from the BABY HUG trial
Pediatric Blood & Cancer, 10/13/09 Relevance Score: 87%

Vaccines for preventing invasive salmonella infections in people with sickle cell disease
Cochrane Reviews, 10/23/09 Relevance Score: 82%

Severe sickle cell disease – pathophysiology and therapy
Biology of Blood and Marrow Transplantation, 10/15/09 Relevance Score: 81%