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Tumour angiogenesis: Its mechanism and therapeutic implications in malignant gliomas
Journal of Clinical Neuroscience, 08/03/09
Wong MLH et al. - Glioblastoma multiforme (GBM) is one of the most angiogenic tumours in humans, thus rendering it an ideal target for anti-angiogenic treatment. Most angiogenesis inhibitors are not highly effective as a monotherapy; however can be combined safely with other adjuvant therapies, in particular temozolomide and concurrent radiotherapy. Such combinations may hold the greatest potential for superior therapeutic efficacy because each component therapy is attacking a slightly different part of the oncogenic machinery.
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Today in Basic Science/Genetics...keeping you current
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Multi-step binding of ADAMTS-13 to von Willebrand factor
Journal of Thrombosis and Haemostasis, 12/02/09
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Today in Neurologic Oncology...keeping you current
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FDA Drug Approval Summary: Bevacizumab (Avastin) as Treatment of Recurrent Glioblastoma Multiforme
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Most primary central nervous system diffuse large B-cell lymphomas occurring in immunocompetent individuals belong to the nongerminal center subtype: a retrospective analysis of 31 cases
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KIR and HLA Genotypes Are Associated with Disease Progression and Survival following Autologous Hematopoietic Stem Cell Transplantation for High-Risk Neuroblastoma
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