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Tumour angiogenesis: Its mechanism and therapeutic implications in malignant gliomas
Journal of Clinical Neuroscience, 08/03/09
Wong MLH et al. - Glioblastoma multiforme (GBM) is one of the most angiogenic tumours in humans, thus rendering it an ideal target for anti-angiogenic treatment. Most angiogenesis inhibitors are not highly effective as a monotherapy; however can be combined safely with other adjuvant therapies, in particular temozolomide and concurrent radiotherapy. Such combinations may hold the greatest potential for superior therapeutic efficacy because each component therapy is attacking a slightly different part of the oncogenic machinery.
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Today in Basic Science/Genetics...keeping you current
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Overexpression and activation of epidermal growth factor receptor in hemangioblastomas
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Today in Neurologic Oncology...keeping you current
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Prognostic significance of histological grading, p53 status, YKL-40 expression, and IDH1 mutations in pediatric high-grade gliomas
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