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Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines
Cancer, 07/28/09
Drozdov I et al. – Lung and GI NET proliferation was autoregulated by 5–HT through alterations in ERK and JNK signaling. Targeting NET cells with 5–HT2 receptor antagonists and 7–HTP reversed proliferation. The current results indicated that 5–HT2 receptor subtype–specific antagonists may represent a viable antiproliferative therapeutic strategy.
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