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See Latest ArticlesLiver-intestine cadherin predicts microvascular invasion and poor prognosis of hepatitis B virus-positive hepatocellular carcinoma
Cancer, 07/27/09
Ding ZB et al. – Study reports that liver-intestine cadherin (LI-cadherin) is predictive of microvascular invasion and poor prognosis of HBV-positive hepatocellular carcinoma (HCC), and would be a potential useful intervention target for HCC.
Methods- An investigation of the role of LI-cadherin in tumor invasion and prognosis of human HBV-positive HCC
- LI-cadherin expression in HBV-positive HCC cell lines with low- and high-invasive potentials was evaluated by Western-blot, IFC, and RT-PCR analyses
- The role of LI-cadherin in tumor invasion was also evaluated in vitro by siRNA
- Prognostic significance of LI-cadherin was validated in a cohort of HBV-positive HCC pts by IHC and WB
- High levels of LI-cadherin mRNA and protein found in high-invasive HCCLM3 vs low-invasive PLC/PRF/5 and Hep3B cell line
- Cell migration, adhesion to extracellular matrix, and matrigel invasion were reduced after LI-cadherin knockdown in HCCLM3 cells
- IHC analysis of 255 HBV-positive HCC cases: overexpression of LI-cadherin was well correlated with microvascular invasion
- This was confirmed by WB in 32 tumor tissues
- Overexpression of LI-cadherin was strongly associated with shorter overall survival and higher incidence of tumor recurrence
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