Oncology Medical News about sickle cell disease

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The excess burden of stroke in hospitalized adults with sickle cell disease
American Journal of Hematology, 07/23/09

Strouse JJ et al. – The results suggest that the rate of stroke in SCD peaks in older adults and is three–fold higher than rates previously reported in African–Americans of similar age (35–64 years) without SCD. Stroke in SCD is associated with several known adult risk factors for ischemic and hemorrhagic stroke. Studies for the primary and secondary prevention of stroke in adults with SCD are urgently needed.

Exclusive Author Commentary
John J. Strouse, 07/24/09

Stroke and silent infarcts are recognized as one of the most morbid complications of sickle cell disease in children. Transfusion is an effective therapy for the primary and secondary prevention of stroke in this group, but has not been studied in adults because strokes were perceived to be less common. This study and a recent study demonstrating neurocognitive impairment in adults with sickle cell disease and no prior stroke (Vinchinsky et al. American Society of Hematology Meetinng Dec 2008) , support the importance of evaluating adults with sickle cell disease for stroke and cognitive impairment.

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Vaccines for preventing invasive salmonella infections in people with sickle cell disease
Cochrane Reviews, 10/23/09 Relevance Score: 83%

Severe sickle cell disease – pathophysiology and therapy
Biology of Blood and Marrow Transplantation, 10/15/09 Relevance Score: 83%

Red grape skin extract could be new treatment for sickle cell disease patients
EurekAlert, 10/23/09 Relevance Score: 82%

Circulating erythrocyte-derived microparticles are associated with coagulation activation in sickle cell disease
Haematologica, 10/12/09 Relevance Score: 82%

Outcome of hematopoietic cell transplantation in children with sickle cell disease, a single center's experience
Bone Marrow Transplantation, 10/01/09 Relevance Score: 81%