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Patients with both basal and squamous cell carcinomas are at a lower risk of further basal cell carcinomas than patients with only a basal cell carcinoma
Journal of the American Academy of Dermatology, 07/29/09

Ramachandran S et al. - In a trial to assess the risks of developing a subsequent basal cell carcinoma (BCC) in pts who developed a BCC and a squamous cell carcinoma (SCC) and compared them with pts who developed BCC only, it was reported that pts who develop a BCC are similar to pts who develop both a BCC and SCC, confirming the overlap of causative factors. Pts who develop both BCC and SCC are less likely to develop BCCs compared with pts who develop BCC only.

Methods

1040 pts who developed BCC only were compared with 140 pts who developed BCC and SCC to see whether the latter group included a high proportion of risk phenotypes (eg, male sex and fair skin).
The number of BCCs developing per yr were compared in the 2 groups (174 BCC only and 71 BCC/SCC) during a 5-yr period after initial BCC presentation.

Results

The BCC/SCC group demonstrated a significantly lower BCC/yr rate than BCC only group.
Rate of development of further BCC during 5-yr follow-up was lower in the BCC/SCC group because a smaller number of pts developed subsequent BCC and not because the same proportion of pts developed lesions but in smaller numbers.
After 5 yrs of follow-up, 51.1% of BCC and 74.6% of BCC/SCC cases were free from a subsequent BCC.
Logistic regression analysis corrected for age at initial presentation confirmed that pts with BCC/SCC were less likely to develop a further BCC during the 5 yrs after initial presentation.

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