Oncology Medical News about Helicobacter pylori, gastric cancer

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Meta-analysis: can Helicobacter pylori eradication treatment reduce the risk for gastric cancer?
Annals of Internal Medicine, 07/23/09

Fuccio L et al. - In a study to determine whether Helicobacter pylori eradication treatment can reduce risk for gastric cancer, it was shown that H pylori eradication treatment seems to reduce gastric cancer risk.

Methods

PubMed, EMBASE, Cochrane Library, Google Scholar, and online clinical trial registers through 31 January 2009, without language restrictions were used.
Randomized trials were used that compared eradication treatment with no treatment in H pylori–positive pts and that assessed gastric cancer or progression of preneoplastic lesions during follow-up.
2 authors independently reviewed articles and extracted data.

Results

7 studies met inclusion criteria, 1 of which was excluded from pooled analysis because of clinical and methodological heterogeneity.
All studies were performed in areas with high incidence of gastric cancer, mostly in Asia.
Overall, 37 of 3388 (1.1%) treated pts developed gastric cancer vs 56 of 3307 (1.7%) untreated (control) participants.
In a pooled analysis of 6 studies with a total of 6695 participants followed from 4 to 10 yrs, relative risk for gastric cancer was 0.65.

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Helicobacter pylori lipopolysaccharides upregulate Toll-like receptor 4 expression and proliferation of gastric epithelial cells via MEK1/2-ERK1/2 MAP kinase pathway
Infection and Immunity, 11/16/09 Relevance Score: 89%

Cost-Effectiveness of Eradication of Helicobacter pylori in Gastric Cancer Survivors After Endoscopic Resection of Early Gastric Cancer
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Clinicopathological Features and Prognostic Factors of Proximal Gastric Carcinoma in a Population with High Helicobacter pylori Prevalence: A Single-Center, Large-Volume Study in Korea
Annals of Surgical Oncology, 11/09/09 Relevance Score: 88%

Cancer: New Explanation Of Asian Paradox
ScienceDaily, 10/29/09 Relevance Score: 88%