Oncology Medical News about Pelvic radiotherapy, Vaginal brachytherapy, Quality of life, Endometrial Cancer

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Quality of life after pelvic radiotherapy or vaginal brachytherapy for endometrial cancer: First results of the randomized PORTEC-2 trial
Journal of Clinical Oncology, 07/20/09

Nout RA et al. – Study demonstrates that endometrial cancer patients who received external-beam radiotherapy (EBRT) reported significantly higher levels of diarrhea and bowel symptoms, resulting into more limitation of daily activities. In these patients, vaginal brachytherapy provides a better quality of life (QOL), and should be the preferred treatment.

Methods

Aim was to compare the QOL among women with endometrial cancer who undergo pelvic radiotherapy vs EBRT or vaginal brachytherapy (VBT)
QOL was evaluated by using:
- European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30, and
- Subscales from the prostate cancer module, PR-25, and ovarian cancer module, OV-28
427 pts between 2002 and 2006 were accrued; 214 randomly assigned to EBRT, and 213 to VBT
81% were evaluable for QOL; outcomes were analyzed at a median f/u of 2 yrs

Results

At baseline after surgery, patient functioning was at the lowest level, and it increased during and after radiotherapy to reach a plateau after 12 mo
Pts in the VBT group reported:
- Better social functioning and lower symptom scores for diarrhea, fecal leakage
- The need to stay close to the toilet, and
- Limitation in daily activities because of bowel symptoms
At baseline, 15% of pts were sexually active; this increased to 39% during the first year
Sexual functioning and symptoms did not differ between the treatment groups

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Urinary, climacteric and sexual symptoms 1 year after treatment of cervical cancer without brachytherapy
Journal of Psychosomatic Obstetrics and Gynecology, 12/01/09 Relevance Score: 96%%

Self-reported symptoms of faecal incontinence among long-term gynaecological cancer survivors and population-based controls
European Journal of Cancer, 11/24/09 Relevance Score: 96%%

Health-related quality of life in long-term survivors of testicular cancer
Journal of Clinical Oncology, 11/02/09 Relevance Score: 94%%

Current developments in the radiotherapy approach to elderly and frail patients with glioblastoma multiforme
Expert Review of Anticancer Therapy, 11/12/09 Relevance Score: 93%%

Quality of life supersedes the classic prognosticators for long-term survival in locally advanced non-small-cell lung cancer: An analysis of RTOG 9801
Journal of Clinical Oncology, 11/02/09 Relevance Score: 90%%