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Epidermal growth factor receptor (EGFR) expression in periocular and extraocular sebaceous carcinoma
Journal of Cutaneous Pathology, 08/04/09

Ivan D et al. – In a study to examine epidermal growth factor receptor (EGFR) expression in periocular and extraocular sebaceous carcinoma, the results underscore the divergent mechanisms underlying the tumorigenesis of periocular and extraocular sebaceous carcinoma and suggest an association between aggressive behavior and increased EGFR expression in extraocular sebaceous carcinoma.

Methods

EGFR levels were evaluated by immunohistochemistry (IHC), comparing its expression between periocular and extraocular tumors and assessed EGFR mutation status.
IHC was performed in 36 cases: 19 periocular and 17 extraocular (10 associated with Muir-Torre syndrome—MTS).
EGFR IHC was scored for percentage of positive cells (<5%, 5–25%, 26–50%, >50%) and intensity (+1 = low , +2 = moderate , +3 = high).

Results

Extraocular carcinomas showed markedly increased levels of EGFR when compared with periocular carcinoma cases, both in terms of distribution (88% were >25% of tumor cells vs 16%) and intensity (77% were 2+ or 3+ vs. 21%).
Among extraocular cases, there was significantly lower EGFR expression in MTS-related cases.
No EGFR mutations were identified.

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