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See Latest ArticlesNKG2D-mediated immunity underlying paroxysmal nocturnal haemoglobinuria and related bone marrow failure syndromes
British Journal of Haematology, 07/09/09
Hanaoka N et al. - Clinical courses of patients with PNH and AA showed a close association of the expression of NKG2D ligands with BM failure and a favourable response to immunosuppressive therapy. The authors therefore propose that NKG2D-mediated immunity may underlie the BM failure in PNH and its-related marrow diseases.
Hideki Nakakuma, 07/09/09
| To draw a conclusion, a large scale of analysis is required. However, we authors propose the pathophysiological significance of the NKG2D-mediated immunity: 1) A model for molecular pathogenesis of bone marrow failure syndromes (BFS) including PNH, aplastic anemia, and MDS, 2) Of help for early diagnosis and development of novel therapy for BFS, 3) A clue to etiology of BFS, 4) Of help for study of immune escape of affected cells including cancer cells. |
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