Your Article Summary
See Latest ArticlesThe novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias
Molecular Cancer, 07/02/09
Hesson LB et al. - The study shows the hypermethylation profile of RASSF genes in leukaemias is distinct from that of solid tumours and represents the first report of inactivation of RASSF6 or RASSF10 in cancer. These data show epigenetic inactivation of RASSF6 and RASSF10 is an extremely frequent event in the pathogenesis of childhood leukaemia. This study also warrants further investigation of the newly identified RASSF member RASSF10 and its potential role in leukaemia.
Related Articles
Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia
British Journal of Haematology, 10/05/09
Relevance Score: 68%
Childhood cancer mortality in Europe, 1970–2007
European Journal of Cancer, 10/14/09
Relevance Score: 67%
Extracorporeal membrane oxygenation as a rescue therapy for leukaemic children with pulmonary failure
British Journal of Haematology, 10/16/09
Relevance Score: 64%
Prognostic relevance of TLX3 (HOX11L2) expression in childhood T-cell acute lymphoblastic leukaemia treated with Berlin–Frankfurt–Münster (BFM) protocols containing early and late re-intensification elements
British Journal of Haematology, 10/16/09
Relevance Score: 64%
Survival After Second Primary Neoplasms of the Brain or Spinal Cord in Survivors of Childhood Cancer: Results From the British Childhood Cancer Survivor Study
Journal of Clinical Oncology, 10/06/09
Relevance Score: 46%
Today in Leukemia/Lymphoma...keeping you current
Receive free subspecialty "5-minute updates" via email
Impact of additional chromosomal aberrations and BCR-ABL kinase domain mutations on the response to nilotinib in Philadelphia chromosome-positive chronic myeloid leukemia
Haematologica, 12/20/09
Nilotinib As Front-Line Treatment for Patients With Chronic Myeloid Leukemia in Early Chronic Phase
Journal of Clinical Oncology, 12/20/09
Cytogenetics of long-term survivors of ETV6-RUNX1 fusion positive acute lymphoblastic leukemia
Genes, Chromosomes and Cancer, 12/19/09
Today in Pediatric Heme/Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
Pharmacogenetic risk factors for altered bone mineral density and body composition in pediatric acute lymphoblastic leukemia
Haematologica, 12/19/09
Early elevation of C-reactive protein correlates with severe infection and non-relapse mortality in children undergoing allogeneic stem cell transplantation
Biology of Blood and Marrow Transplantation, 12/17/09
Unrelated cord blood transplantation in pediatric patients: a report from Saudi Arabia
Bone Marrow Transplantation, 12/17/09