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See Latest ArticlesGabapentin for the treatment of pain related to radiation-induced mucositis in patients with head and neck tumors treated with intensity-modulated radiation therapy
Head & Neck, 07/08/09
Ad VB et al. - In a trial to evaluate the efficacy of gabapentin for treatment of pain syndrome related to radiation-induced mucositis in pts with head and neck tumors, gabapentin appears promising in reducing the need for narcotic pain medication for pts with head and neck malignancies treated with intensity-modulated radiation therapy (IMRT).
Methods- 30 cases of head and neck malignancies treated with radiotherapy were analyzed.
- By using a median dose of 2700 mg/day of gabapentin, only 10% of pts required additional narcotic pain medications for adequate pain relief during the third and fourth week of treatment, despite grade 2 or higher mucositis present in 56% and 73% of the pts, respectively.
- During the last wks of IMRT, only 35% of pts required additional narcotics for pain control, despite the presence of grade 2 or higher mucositis in 80% of cases.
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