Your Article Summary
See Latest ArticlesDNA double-strand break repair activities in mammary epithelial cells-influence of endogenous p53 variants
Carcinogenesis, 07/02/09
Wiesmuller L et al. - The authors show that depending on the individual mutation, p53 mutants retain more or less partial DSB repair downregulatory activities when compared with loss of p53. All in all, relative effects on distinct DSB repair pathways and discrimination between HR substrates with perfectly versus imperfectly homologous sequences represent good markers for a p53 defect due to a specific mutation. Thus, advanced DSB repair analysis may serve as a novel assay for the functional classification of p53 mutations.
Related Articles
DNA damage induced by cis- and carboplatin as indicator for in vitro sensitivity of ovarian carcinoma cells
BMC Cancer, 10/15/09
Relevance Score: 93%
Oxidative DNA damage impairs global sperm DNA methylation in infertile men
Journal of Assisted Reproduction and Genetics, 11/02/09
Relevance Score: 91%
Evaluation of automated and manual commercial DNA extraction methods for the recovery of Brucella spp. DNA from suspensions and spiked swabs
Journal of Clinical Microbiology, 10/23/09
Relevance Score: 89%
Antibodies to DNA: infection or genetics
Lupus, 11/12/09
Relevance Score: 88%
A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA
Proceedings of the National Academy of Sciences of the United States of America, 10/22/09
Relevance Score: 87%
Today in Basic Science/Genetics...keeping you current
Receive free subspecialty "5-minute updates" via email
Target genes suitable for silencing approaches and protein product interference in ovarian epithelial cancer
Cancer Treatment Reviews, 12/04/09
Dysregulation of Platelet-Derived Growth Factor beta-Receptor Expression by deltaNp73 in Neuroblastoma
Molecular Cancer Research, 12/04/09
Tissue transglutaminase 2 as a biomarker of cervical intraepithelial neoplasia (CIN) and its relationship to p16INK4A and nuclear factor kappaB expression
Virchows Archiv, 12/04/09