Oncology Medical News about pancreatic cancer;management;prognosis

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Management and prognosis of pancreatic cancer over a 30-year period
British Journal of Cancer, 07/02/09

David M et al. - In a trial to examine changes in diagnostic assessment, patterns of care, and survival over time for pancreatic cancers (PCa), it seems that over a 30-yr period, there were minor changes in stage at diagnosis, resection for cure, and prognosis of PCa, although there were improvements in diagnostic modalities. PCa still represents a major challenge in oncology.

Methods

2986 cases of PCa from the Digestive Cancer Registry of Burgundy over a 30-yr period were considered.
Non-conditional logistic regressions were carried out to identify factors associated with resection for cure and with use of chemotherapy.

Results

Ultrasonography and computed tomography progressively have become the major diagnostic procedures.
There was a slight improvement in stage: the proportion of stage I–II was 2.8% in the 1976–1980 period and 8.8% in the 2001–2005 period.
There was a similar trend in the proportion of cases resected for cure, corresponding percentages being 4.5 and 11.3%, respectively.
5-yr relative survival increased from 2.0 to 4.2%.
In the multivariate relative survival analysis, the period remained a significant prognostic factor.
Stage, sex, age, and histology were independent prognostic factors.

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