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Management and prognosis of pancreatic cancer over a 30-year period
British Journal of Cancer, 07/02/09

David M et al. - In a trial to examine changes in diagnostic assessment, patterns of care, and survival over time for pancreatic cancers (PCa), it seems that over a 30-yr period, there were minor changes in stage at diagnosis, resection for cure, and prognosis of PCa, although there were improvements in diagnostic modalities. PCa still represents a major challenge in oncology.

• 2986 cases of PCa from the Digestive Cancer Registry of Burgundy over a 30-yr period were considered.
• Non-conditional logistic regressions were carried out to identify factors associated with resection for cure and with use of chemotherapy.

• Ultrasonography and computed tomography progressively have become the major diagnostic procedures.
• There was a slight improvement in stage: the proportion of stage I–II was 2.8% in the 1976–1980 period and 8.8% in the 2001–2005 period.
• There was a similar trend in the proportion of cases resected for cure, corresponding percentages being 4.5 and 11.3%, respectively.
• 5-yr relative survival increased from 2.0 to 4.2%.
• In the multivariate relative survival analysis, the period remained a significant prognostic factor.
• Stage, sex, age, and histology were independent prognostic factors.

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