Oncology Medical News about chronic myeloid leukemia

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Long-term outcome of patients with chronic myeloid leukemia treated with second generation tyrosine kinase inhibitors after imatinib failure is predicted by the in vitro sensitivity of BCR-ABL kinase domain mutations
Blood, 07/02/09

Jabbour E et al. - The correlations with overall survival were not seen for advanced phases. Mutation scoring can predict outcome in CML-CP with imatinib failure treated with second generation TKIs and can help in therapy selection. More complex prognostic models will be required for advanced stages of disease.

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Dasatinib 100 mg once daily minimizes the occurrence of pleural effusion in patients with chronic myeloid leukemia in chronic phase and efficacy is unaffected in patients who develop pleural effusion
Cancer, 11/25/09 Relevance Score: 83%%

Chronic myeloid leukemia: a prospective comparison of interphase fluorescence in situ hybridization and chromosome banding analysis for the definition of complete cytogenetic response, a study of the GIMEMA CML WP
Blood, 10/09/09 Relevance Score: 82%%

Epidemiological study on survival of chronic myeloid leukemia (CML) and Ph+ acute lymphoblastic leukemia (ALL) patients with BCR-ABL T315I mutation
Blood, 11/06/09 Relevance Score: 81%%

SUZ12 is a candidate target of the non-canonical WNT pathway in the progression of chronic myeloid leukemia
Genes, Chromosomes and Cancer, 10/28/09 Relevance Score: 81%%

Dasatinib treatment of chronic phase chronic myeloid leukemia: analysis of responses according to preexisting BCR-ABL mutations
Blood, 10/02/09 Relevance Score: 81%%