Your Article Summary
See Latest ArticlesNovel treatment strategies for malignant gliomas using neural stem cells
Neurotherapeutics, 07/01/09
Oh MC et al. - In a review of novel treatment strategies for malignant gliomas using neural stem cells (NSCs), it was concluded that these studies and others on the basic biology of both brain tumor stem cells (BTSCs) and NSCs will be crucial to expanding treatment strategies for malignant gliomas.
Methods- Identification and characterization of endogenous NSCs, especially those in the adult human brain, have inspired new ideas for selectively targeting and destroying malignant gliomas.
- Gliomas consist of a heterogeneous population of cells, and some of these cells have characteristics of cancer stem cells.
- These BTSCs share certain characteristics with normal NSCs.
- It is still unclear whether malignant gliomas in human pts originate from these aberrant BTSCs.
- Cellular and molecular similarities between BTSCs and normal NSCs suggest a common research landscape underlying both normal and cancer stem cell biology, wherein findings of 1 field are relevant to the other.
- The natural tropism of NSCs to gliomas has generated the idea that modified NSCs can deliver modified genes to selectively destroy malignant brain tumor cells, and even BTSCs, while leaving healthy surrounding neurons intact.
Today in Neurologic Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
Critical appraisal of temozolomide formulations in the treatment of primary brain tumors: patient considerations
Cancer Management and Research, 11/05/09
NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide
Journal of Clinical Oncology, 11/12/09
Height, Body Mass Index, and Physical Activity in Relation to Glioma Risk
Cancer Research, 11/02/09