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The combination of docetaxel and cisplatin plus fluorouracil as neoadjuvant chemotherapy in the treatment of T4 stage gastric cancer
Surgical Oncology, 07/02/09
Guo MG et al. - In a review of the use of docetaxel and cisplatin plus fluorouracil as neoadjuvant chemotherapy in treatment of T4 stage gastric cancer, it was concluded that those who responded to docetaxel–cisplatin–fluorouracil, exhibited T downstaging, and subsequently received an R0 resection had a better chance of a cure vs surgery alone, according to a complete 3-yr follow-up.
Methods- Prognosis of local advanced gastric carcinoma is very poor.
- Impact on survival and the effects induced by the triple combination docetaxel–cisplatin–fluorouracil (DCF) as neoadjuvant chemotherapy was evaluated in 24 T4 stage gastric tumor pts.
- They received 2–3 cycles DCF chemotherapy, followed by radical gastric resection.
- Tumor downstaging detected by CT was obtained in 17 of 24 pts.
- Overall 3-yr survival rate was 68.2%.
- Pts who received R0 resection (19/22) showed a 3-yr survival rate of 78.9%.
- T downstaged pts (17/22) showed a higher 3-yr survival rate of 82.4%.
Today in GI Oncology...keeping you current
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Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma
New England Journal of Medicine, 10/22/09
Randomized phase II study of gemcitabine administered at a fixed dose rate or in combination with cisplatin, docetaxel, or irinotecan in patients with metastatic pancreatic cancer
Journal of Clinical Oncology, 11/02/09
Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer
Journal of Clinical Oncology, 10/29/09
Today in Pharmacology/Therapy...keeping you current
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Nonsteroidal anti-inflammatory drugs
Cancer, 10/16/09
Docetaxel versus docetaxel alternating with gemcitabine as treatments of advanced breast cancer: final analysis of a randomised trial
Annals of Oncology, 10/13/09
Lymphoma in patients treated with anti-TNF. Results of the 3-year prospective French RATIO registry.
Annals of Rheumatic Diseases, 10/22/09
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