Your Article Summary
See Latest ArticlesNelfinavir induces mitochondria protection by ERK1/2-mediated mcl-1 stabilization that can be overcome by sorafenib
Investigational New Drugs, 07/01/09
Bruning A et al. - The combination of nelfinavir with sorafenib induced mitochondrial membrane potential disruption and resulted in an improved activity of nelfinavir on ovarian cancer cells. Thus, a combination of these two investigational anti-cancer drugs could be of interest especially because of their unique mechanism of apoptosis induction even in otherwise chemo-resistant human cancer cells.
Related Articles
Upfront, randomized, phase II trial of sorafenib versus sorafenib and low-dose interferon alfa in patients with advanced renal cell carcinoma
Cancer, 11/03/09
Relevance Score: 96%
Use of sorafenib in patients with hepatocellular carcinoma before liver transplantation: A cost-benefit analysis while awaiting data on sorafenib safety
Hepatology, 11/02/09
Relevance Score: 87%
Incidence of brain metastases in renal cell carcinoma treated with sorafenib
Annals of Oncology, 10/29/09
Relevance Score: 87%
Glucose-Regulated Protein 78 Is a Novel Contributor to Acquisition of Resistance to Sorafenib in Hepatocellular Carcinoma
Annals of Surgical Oncology, 10/20/09
Relevance Score: 87%
Beneficial effects of sorafenib on tumor progression, but not on radioiodine uptake, in patients with differentiated thyroid carcinoma
European Journal of Endocrinology, 10/06/09
Relevance Score: 87%
Today in Gynecologic Oncology...keeping you current
Receive free subspecialty "5-minute updates" via email
Activation of hedgehog signaling is not a frequent event in ovarian cancers
Molecular Cancer, 12/08/09
Clinical utility of circulating matrix metalloproteinase-7 (MMP-7), CC chemokine ligand 18 (CCL18) and CC chemokine ligand 11 (CCL11) as markers for diagnosis of epithelial ovarian cancer
Medical Oncology, 12/08/09
Plasma levels of alkylresorcinols and incidence of endometrial cancer
European Journal of Cancer Prevention, 12/08/09
Today in Pharmacology/Therapy...keeping you current
Receive free subspecialty "5-minute updates" via email
Effects of functional electrical stimulation on dysphagia caused by radiation therapy in patients with nasopharyngeal carcinoma
Supportive Care in Cancer, 12/08/09
Is there a role for intensifying induction therapy in acute myeloid leukaemia (AML)?
Best Practice & Research: Clinical Haematology , 12/08/09
Tailoring iron chelation by iron intake and serum ferritin: prospective EPIC study of deferasirox in 1744 patients with transfusion-dependent anemias
Haematologica, 12/08/09