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See Latest ArticlesTumour suppression by p53: the importance of apoptosis and cellular senescence
The Journal of Pathology, 06/30/09
Zuckerman V et al. - Therapeutic strategies aimed at reactivation of p53 in tumours emerge as a promising approach for the treatment of cancer patients. This response involves transcriptional activation or repression of target genes, as well as the recently identified microRNAs, and transcription-independent functions. Importantly, p53 loss of function is required for tumour maintenance.
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