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Uveal melanoma cell-based vaccines express MHC II molecules that traffic via the endocytic and secretory pathways and activate CD8+ cytotoxic, tumor-specific T cells
Cancer Immunology, Immunotherapy, 06/30/09

Bosch JJ et al. - The studies demonstrate that MHC II uveal melanoma vaccines are potent activators of tumor-specific CD4+ and CD8+ T cells and suggest that the non-conventional intracellular trafficking pattern of MHC II may contribute to their enhanced immunogenicity. Since MHC I compatibility is unnecessary for the activation of cytolytic CD8+ T cells, the vaccines could be used in uveal melanoma patients without regard to MHC I genotype.

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Gadd45b and Gadd45g are important for anti-tumor immune responses
European Journal of Immunology, 10/23/09 Relevance Score: 65%%

Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge
Proceedings of the National Academy of Sciences of the United States of America, 10/22/09 Relevance Score: 64%%

Tumor Antigen–Specific FOXP3+ CD4 T Cells Identified in Human Metastatic Melanoma: Peptide Vaccination Results in Selective Expansion of Th1-like Counterparts
Cancer Research, 10/21/09 Relevance Score: 64%%

Lymph node tumor metastases: more susceptible than primary tumors to CD8+ T-cell immune destruction
Trends in Immunology, 10/21/09 Relevance Score: 64%%

Peptide vaccines for patients with acute myeloid leukemia
Expert Review of Vaccines, 10/07/09 Relevance Score: 64%%