Your Article Summary
See Latest ArticlesComplete soft tissue sarcoma resection is a viable treatment option for select elderly patients
Annals of Surgical Oncology, 07/01/09
Lahat G et al. - In a study to evaluate the outcome of elderly pts amenable to complete surgical resection treated at a single institution, it seems that properly selected elderly pts can safely undergo extensive soft tissue sarcoma (STS) resections. Until more effective therapies become available, surgery in the elderly is indicated and remains the best means for STS control.
Methods- Prospectively accrued data were used to identify pts with primary STS age ≥65 yrs (n=325) who underwent complete macroscopic resection at 1 institution.
- Univariable and multivariable analyses were performed to identify prognostic factors.
- Median age at presentation was 72 yrs; 179 pts (55.1%) had associated comorbidities with an ASA score of ≥3.
- Extremity was the most common site (57.1%; n=186), undifferentiated pleomorphic sarcoma the most common histology (60.4%; n=197); 232 (71.2%) were high grade, 222 (68.3%) were >5 cm.
- 30-day postoperative mortality was 0.9% (n=3); overall complication rate was 30.7% (n=100), and mean postoperative hospital stay was 9 days.
- Estimated median survival was 96 mos, 5-yr disease-specific survival (DSS) was 63%.
- Multivariable analysis identified age ≥75 yrs, tumor size: 5–15 vs <5 cm, or >15 vs <5 cm, and high-grade as significant independent adverse prognostic factors.
- Compared with pts aged 65–74 yrs, older pts had more high-grade tumors, received chemotherapy less often, developed different patterns of recurrence, and exhibited a shorter median survival (70 mos).
Related Articles
Coincident expression of beta-catenin and cyclin D1 in endometrial stromal tumors and related high-grade sarcomas
Modern Pathology, 11/11/09
Relevance Score: 92%
Histiocytic sarcoma with interdigitating dendritic cell differentiation: A case report with fine needle aspiration cytology and review of literature
Diagnostic Cytopathology, 10/28/09
Relevance Score: 90%
Skeletal metastasis from sarcoma: a report of three cases
European Journal of Orthopaedic Surgery & Traumatology, 10/23/09
Relevance Score: 89%
Alveolar soft-part sarcoma of the tongue in a 17-month-old
ENT Journal, 10/19/09
Relevance Score: 89%
Radiological assessment following thermoradiation therapy for primary pleural synovial sarcoma: case report
Medical Oncology, 10/19/09
Relevance Score: 89%
Today in Soft Tissue/Sarcoma...keeping you current
Receive free subspecialty "5-minute updates" via email
Immunoprofile of mesenchymal chondrosarcoma: aberrant desmin and EMA expression, retention of INI1, and negative estrogen receptor in 22 female-predominant central nervous system and musculoskeletal cases
Annals of Diagnostic Pathology, 12/11/09
Birth characteristics and the risk of childhood rhabdomyosarcoma based on histological subtype
British Journal of Cancer, 12/11/09
HER-2 targeted treatment of osteosarcoma: the challenges of developing targeted therapy and prognostic factors for rare malignancies
Expert Opinion in Pharmacotherapy, 12/11/09