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Estrogen receptor overexpression in malignant minor salivary gland tumors of the sinonasal tract
Otolaryngology Head and Neck Surgery, 07/01/09

Luo SD et al. - In a study to identify the expression of estrogen receptors in malignant minor salivary gland tumors of the sinonasal tract, it was determined that adenoid cystic carcinoma was the most common form of tumor, but the prognosis was poor. Most of the cases were positive for expression of estrogen receptor α, which suggests that hormone therapy may have a role in the management of certain minor salivary gland tumors of the paranasal sinus and nasal cavity.

• A retrospective review of a pathology database identified 17 pts with malignant salivary gland tumors.
• Clinicopathologic data were collected, and immunohistochemical staining for estrogen receptor α and β was performed.

• Among the malignant tumors, adenoid cystic carcinoma was the predominant histologic type.
• In addition to epistaxis and nasal obstruction, headache, facial, or ocular symptoms were also commonly noted.
• 75% of cases of adenoid cystic carcinoma were positive for estrogen receptor α.
• Only 17% of cases of adenoid cystic carcinoma were positive for estrogen receptor β.

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