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Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal carcinomatosis from colorectal and gastrointestinal origin shows acceptable morbidity and high survival
European Journal of Surgical Oncology, 07/01/09

Hagendoorn J et al. - In a study to examine the use of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with peritoneal carcinomatosis of colorectal and gastrointestinal origin, it was concluded that in well-selected pts referred to a specialized institution, CS–HIPEC has acceptable morbidity and high survival rate.

Methods

67 pts underwent a laparotomy.
Complete cytoreduction could be performed in 49 pts, who underwent 53 CS–HIPEC procedures.
All had peritoneal carcinomatosis originating from primary colorectal, cecal, appendiceal, and gastric tumors.

Results

In pts who underwent CS–HIPEC, an R0 resection could be achieved in 4%, R1 in 88%, and R2 in 8%.
30-day mortality was 0; 1 pt died in-hospital after 10 wks.
Median hospital stay was 12 days.
Overall morbidity was 43%, including extended gastroparesis (11%), anastomotic failure (11%), and intra-abdominal abscess (9%).
Mean time to clinical recurrence was 12 mos.
Actuarial 1-yr survival was 88% and 2-yr survival was 75%.

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