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Surgical specialty, surgical unit volume, and mortality after oesophageal cancer surgery
European Journal of Surgical Oncology, 06/30/09

Leigh Y et al. - In a trial to investigate the effects of surgical specialty and volume on mortality after oesophagectomy, it was shown that pts treated by general surgeons in low-volume hospitals had worse mortality outcomes than those treated by general surgeons in high-volume hospitals or by cardiothoracic surgeons. This is important because a majority of pts who underwent oesophagectomy for cancer were in this high-mortality risk group.

• Hospital Episode Statistics for oesophagectomy were analyzed for cancer (n=9034 cases), linked to data from death certificates, in England from 1998 to 2003.

• After adjustment for pts' age, sex, and deprivation score, the odds ratio (OR) for death of general surgeons' (GS) pts, compared with cardiothoracic surgeons' (CTS) pts, was significantly high: 1.62 at 90 days.
• Odds ratio for high-volume GS pts was not significantly different from that for high-volume CTS pts.
• Odds ratio for low-volume GS pts vs high-volume CTS pts was significantly high: 1.72 at 30 days and 1.48 at 90 days.

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Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma
New England Journal of Medicine, 10/22/09

Randomized phase II study of gemcitabine administered at a fixed dose rate or in combination with cisplatin, docetaxel, or irinotecan in patients with metastatic pancreatic cancer
Journal of Clinical Oncology, 11/02/09

Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer
Journal of Clinical Oncology, 10/29/09

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