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See Latest ArticlesDexamethasone and hypoxia upregulate CXCR4 expression in myeloma cells
Leukemia and Lymphoma, 07/02/09
Kim SW et al. - Incubation of cells under hypoxic conditions (1% O2) also induced upregulation of CXCR4 in the cytoplasm and on the cell surface and enhanced chemotaxis in response to stromal cell-derived factor-1 (SDF-1). Cell surface CXCR4 expression was more prominent in annexin V-positive apoptotic cells. Given the roles of the SDF-1/CXCR4 axis in the development and progression of myeloma, CXCR4-downregulating agents may enhance the antitumor effects of dexamethasone.
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Today in Basic Science/Genetics...keeping you current
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Knockdown of peroxisome proliferator-activated receptor-beta induces less differentiation and enhances cell–fibronectin adhesion of colon cancer cells
Oncogene, 11/25/09
A novel translational approach for human malignant pleural mesothelioma: heparanase-assisted dual virotherapy
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Today in Dermatologic Oncology...keeping you current
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Loco-regional control after postoperative radiotherapy for patients with regional nodal metastases from melanoma
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Expression of MMP-10, MMP-21, MMP-26, and MMP-28 in Merkel cell carcinoma
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Isolation and Characterization of Spheroid Cells from Human Malignant Melanoma Cell Line WM-266-4
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Today in Pharmacology/Therapy...keeping you current
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Sorafenib, a dual Raf kinase/vascular endothelial growth factor receptor inhibitor has significant anti-myeloma activity and synergizes with common anti-myeloma drugs
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