Oncology Medical News about leukemic human CD34+ cells

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Repression of BMI1 in normal and leukemic human CD34+ cells impairs self-renewal and induces apoptosis
Blood, 06/29/09

Rizo A et al. - The phenotypes were also associated with increased expression levels of p14ARF and p16INK4A. Together data indicate that BMI1 expression is required for maintenance and self-renewal of normal and leukemic stem and progenitor cells and that expression of BMI1 protects cells against oxidative stress.

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Molecular and functional analysis of the stem cell compartment of chronic myelogenous leukemia reveals the presence of a CD34- cell population with intrinsic resistance to imatinib
Blood, 11/09/09 Relevance Score: 82%%

Human induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders
Blood, 10/09/09 Relevance Score: 82%%

Co-treatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplasm cells
Blood, 11/02/09 Relevance Score: 80%%

In vivo dynamics of human cord blood-derived CD34- SCID-repopulating cells using intra-bone marrow injection
Leukemia, 10/05/09 Relevance Score: 80%%

Clinical relevance of thyroid dysfunction on human haematopoiesis - biochemical and molecular studies
European Journal of Endocrinology, 11/19/09 Relevance Score: 79%%