Oncology Medical News about leukemic human CD34+ cells

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Repression of BMI1 in normal and leukemic human CD34+ cells impairs self-renewal and induces apoptosis
Blood, 06/29/09

Rizo A et al. - The phenotypes were also associated with increased expression levels of p14ARF and p16INK4A. Together data indicate that BMI1 expression is required for maintenance and self-renewal of normal and leukemic stem and progenitor cells and that expression of BMI1 protects cells against oxidative stress.

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