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Impact of age and gender on the clinicopathological characteristics of bladder cancer
Indian Journal of Urology, 06/29/09

Gupta P et al. - Data suggest that transitional cell carcinoma (TCC) is the predominant cancer, with significant male preponderance among Indian patients. Younger patients have low-grade disease; hematuria is the most common presentation. Greater awareness is needed not to overlook bladder cancer.

Methods

Study to determine the impact of age and gender on the clinicopathological characteristics of histologically confirmed bladder cancer in India
From Jan 2001-June 2008, records of pts (n=561) with bladder cancer were evaluated for:
- Age and gender at presentation
- Clinical symptoms
- Cystoscopic finding
- History of smoking, and
- Histopathological characteristics

Results

97% of the pts presented with painless hematuria
Mean age: 60.2 ± 4.4 yrs; male to female ratio: 8.6:1
TCC was the most common histological variety, which was present in 97.71% of the pts
26% pts had muscle invasive disease at the time of presentation:
- However, 34.5% pts did not show any evidence of detrusor muscle
- In pts with nonmuscle-invasive bladder carcinoma, 55% had p Ta while 45% had p T1
Overall, 44.7% pts had low-grade disease
Among pts <60 yrs, low-grade and low-stage disease were more prevalent vs those >60 yrs
Incidence of smoking was much higher among males vs females

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High frequency of tumor cells with nuclear Egr-1 protein expression in human bladder cancer is associated with disease progression
BMC Cancer, 11/13/09 Relevance Score: 70%

Evidence-based Principles of Bladder Cancer and Diet
Urology, 10/21/09 Relevance Score: 70%

Incidence analyses of bladder cancer in the Nile delta region of Egypt
Cancer Epidemiology, 10/20/09 Relevance Score: 70%

Biomarkers in bladder cancer
BJU International, 10/01/09 Relevance Score: 70%

Diagnosis and Treatment of Bladder Cancer
American Family Physician, 10/01/09 Relevance Score: 70%