Oncology

Your Article Summary

See Latest Articles

Podoplanin expression identified in stromal fibroblasts as a favorable prognostic marker in patients with colorectal carcinoma
Oncology (Karger), 06/26/09

Yamanashi T et al. - In a trial to investigate the clinicopathological significance of podoplanin expression in stromal fibroblasts in pts with colorectal cancer (CRC), it was shown that a positive podoplanin expression in stromal fibroblasts could have a protective role against CRC cell invasion and is a significant indicator of a good prognosis in pts with advanced CRC, supported by biological analysis showing that podoplanin expression in cancer-associated fibroblasts (CAFs) is associated with decreased CRC cell invasion.

• Podoplanin was selected as an upregulated marker in CAF from a DNA microarray experiment.
• Podoplanin was identified as an upregulated gene.
• Immunohistochemical podoplanin expression was investigated in 120 pts with advanced CRC, and its clinicopathological significance was examined.
• Biological function of podoplanin expression was also assessed by a coculture invasion assay with CRC cell lines such as HCT116 and HCT15.

• Podoplanin expression was exclusively confined to stromal fibroblasts and absent in tumor cells.
• Podoplanin is absent in normal stroma except for lymphatic vessels.
• Staining was considered positive when >30% of the cancer stroma was stained.
• Positive podoplanin expression was significantly correlated with a more distal tumor localization and a shallower depth of tumor invasion.
• Univariate analysis revealed that negative podoplanin expression in stromal fibroblasts was significantly associated with reduced disease-specific survival and disease-free survival (DFS).
• Multivariate analysis revealed that negative podoplanin expression and lymph node metastasis were significantly associated with DFS.
• CRC cell invasion was augmented by co-culture with CAFs that were treated with siRNA for podoplanin.

Today in Colorectal Cancer/Polyps...keeping you current

Receive free subspecialty "5-minute updates" via email

Knockdown of peroxisome proliferator-activated receptor-beta induces less differentiation and enhances cell–fibronectin adhesion of colon cancer cells
Oncogene, 11/25/09

A blood-based biomarker panel for stratifying current risk for colorectal cancer
International Journal of Cancer, 11/25/09

iNOS activity is necessary for the cytotoxic and immunogenic effects of doxorubicin in human colon cancer cells
Molecular Cancer, 11/24/09

 See all of Colorectal Cancer/Polyps