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Outcomes of patients with stage III non-small cell lung cancer treated with chemotherapy and radiation with and without surgery
Cancer, 06/26/09

Caglar HB et al. - In a study to identify the factors associated with improved outcome after treatment for stage III non-small cell lung cancer (NSCLC), it seems that stage at the time of treatment (stage IIIA vs stage IIIB) and use of surgery were the only factors associated with improved outcome.

Methods

A retrospective review of stage III NSCLC pts was done.
Pts were followed for toxicity, local and distant failure, and overall survival (OS).
Multivariate Cox logistic regression analysis was used to determine factors associated with treatment outcome.

Results

144 pts received concurrent chemoradiation (CRT) for stage III NSCLC.
80 of 144 pts were men (56%), and median age was 61 yrs.
62 pts (43%) had stage IIIA NSCLC, and 82 pts (57%) had stage IIIB NSCLC.
Radiotherapy (RT) was given concurrently with chemotherapy to all pts; 100 pts (69%) received CRT without surgery, and 44 pts (31%) received with neoadjuvant CRT followed by surgical resection.
Median RT dose was 60 grays (Gy).
Median follow-up was 15 mos, median potential follow-up was 37 mos, and median OS was 22 mos.
1-yr and 2-yr survival rates were 68% and 47%, respectively.
Among the 44 pts who underwent resection, median survival was 61 mos, and 2-yr survival rate was 73%.
On multivariate analysis, stage at the time of treatment (stage IIIA vs stage IIIB) and use of surgery were the only factors associated with improved outcome.

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