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See Latest ArticlesOutcomes of patients with stage III non-small cell lung cancer treated with chemotherapy and radiation with and without surgery
Cancer, 06/26/09
Caglar HB et al. - In a study to identify the factors associated with improved outcome after treatment for stage III non-small cell lung cancer (NSCLC), it seems that stage at the time of treatment (stage IIIA vs stage IIIB) and use of surgery were the only factors associated with improved outcome.
Methods- A retrospective review of stage III NSCLC pts was done.
- Pts were followed for toxicity, local and distant failure, and overall survival (OS).
- Multivariate Cox logistic regression analysis was used to determine factors associated with treatment outcome.
- 144 pts received concurrent chemoradiation (CRT) for stage III NSCLC.
- 80 of 144 pts were men (56%), and median age was 61 yrs.
- 62 pts (43%) had stage IIIA NSCLC, and 82 pts (57%) had stage IIIB NSCLC.
- Radiotherapy (RT) was given concurrently with chemotherapy to all pts; 100 pts (69%) received CRT without surgery, and 44 pts (31%) received with neoadjuvant CRT followed by surgical resection.
- Median RT dose was 60 grays (Gy).
- Median follow-up was 15 mos, median potential follow-up was 37 mos, and median OS was 22 mos.
- 1-yr and 2-yr survival rates were 68% and 47%, respectively.
- Among the 44 pts who underwent resection, median survival was 61 mos, and 2-yr survival rate was 73%.
- On multivariate analysis, stage at the time of treatment (stage IIIA vs stage IIIB) and use of surgery were the only factors associated with improved outcome.
Today in Diagnostics/Radiology...keeping you current
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Risk of dying from prostate cancer in men randomized to screening
Cancer, 10/13/09
Early PSA decrease is an independent predictive factor of clinical failure and specific survival in patients with localized prostate cancer treated by radiotherapy with or without androgen deprivation therapy
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Potential predictive markers of chemotherapy resistance in stage III ovarian serous carcinomas
BMC Cancer, 10/21/09
Today in Lung/Thoracic Oncology...keeping you current
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Oestrogen plus progestin and lung cancer in postmenopausal women (Womens Health Initiative trial): a post-hoc analysis of a randomised controlled trial
The Lancet, 10/12/09
Prognostic and predictive factors in a randomized phase III trial comparing cisplatin-pemetrexed versus cisplatin-gemcitabine in advanced non-small-cell lung cancer
Annals of Oncology, 10/19/09
Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: A randomised, double-blind, phase III study
The Lancet, 10/26/09
Today in Pharmacology/Therapy...keeping you current
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Nonsteroidal anti-inflammatory drugs
Cancer, 10/16/09
Docetaxel versus docetaxel alternating with gemcitabine as treatments of advanced breast cancer: final analysis of a randomised trial
Annals of Oncology, 10/13/09
Lymphoma in patients treated with anti-TNF. Results of the 3-year prospective French RATIO registry.
Annals of Rheumatic Diseases, 10/22/09
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