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p53-Induced ring-H2 protein, a novel marker for poor survival in hepatocellular carcinoma after hepatic resection
Cancer, 06/26/09

Wang XM et al. - In a study to investigate expression of p53-induced RING-H2 protein (PIRH2) and its relation to prognosis in pts with hepatocellular carcinoma (HCC) after hepatic resection, the current data revealed that increased expression of PIRH2 was correlated with poor survival in pts with HCC, indicating that PIRH2 is a novel prognostic marker for HCC.

• Reverse transcriptase-polymerase chain reaction (RT-PCR), quantitative real-time RT-PCR, and Western blot analyses were used to detect expression levels of PIRH2 in 30 samples of HCC tissue and paracarcinomatous liver tissue (PCLT) and in 5 samples of normal liver tissue (NL).
• Immunohistochemical analysis was performed on 122 HCC specimens and follow-up data from those pts were reviewed.

• Both messenger RNA and protein expression levels of PIRH2 were elevated significantly in HCC tissues vs PCLT and NL tissues.
• Increased PIRH2 expression was correlated with vein invasion, Edmondson-Steiner grade, TNM stage, and multiple tumor nodes.
• Pts with HCC who had high PIRH2 expression had shorter overall survival and disease-free survival than patients who had low PIRH2 expression.
• Multivariate Cox regression analysis revealed that high PIRH2 expression was an independent prognostic factor for pts with HCC.

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