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See Latest ArticlesPrognostic and predictive markers of benefit from adjuvant chemotherapy in early-stage non-small cell lung cancer
Journal of Thoracic Oncology, 06/29/09
Custodio AB et al. - Patients with early stage NSCLC are at substantial risk for recurrence even after potentially curative surgical resection, and adjuvant chemotherapy. The current staging system is inadequate for predicting the outcome of treatment and the prognosis in an individual patient. Molecular markers may provide additional information about the likelihood of relapse beyond that obtained from pathologic staging. They may also have value in determining which patients will benefit from adjuvant platinum-based chemotherapy. This review focuses on:
- Approaches and specific markers under study
- Gene expression profiles
- DNA repair pathways
- Class III β-tubulin expression
- Abnormalities in the k-ras oncogene and p53 tumor suppressor gene, and
- DNA methylation markers
Today in Basic Science/Genetics...keeping you current
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Thrombopoietin in normal and neoplastic stem cell development
Best Practice & Research: Clinical Haematology , 12/07/09
Mechanisms of mutations in myeloproliferative neoplasms
Best Practice & Research: Clinical Haematology , 12/07/09
Ursodeoxycholic acid switches oxaliplatin-induced necrosis to apoptosis by inhibiting reactive oxygen species production and activating p53-caspase 8 pathway in HepG2 hepatocellular carcinoma
International Journal of Cancer, 12/07/09
Today in Lung/Thoracic Oncology...keeping you current
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Efficacy of plasma vascular endothelial growth factor in monitoring first-line chemotherapy in patients with advanced non-small cell lung cancer
BMC Cancer, 12/07/09
Phase I Study of Accelerated Conformal Radiotherapy for Stage I Non-Small-Cell Lung Cancer in Patients With Pulmonary Dysfunction: CALGB 39904
Journal of Clinical Oncology, 12/04/09
Management of lung nodules detected by volume CT scanning
New England Journal of Medicine, 12/03/09
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