Your Article Summary
See Latest ArticlesRisk of tumour progression in early-stage hepatocellular carcinoma after radiofrequency ablation
British Journal of Surgery, 06/25/09
Fernandes ML et al. - In a study to quantify the risk of tumour progression beyond the Milan criteria following radiofrequency (RF) ablation for hepatocellular carcinoma (HCC) and to identify factors associated with tumour progression, this study provides clinicians with an objective risk of tumour progression beyond the Milan criteria after RF ablation at multiple time points. Primary technique failure is identified as a risk factor for tumour progression.
Methods- 111 pts (136 tumours) with liver cirrhosis undergoing RF ablation for HCC within Milan criteria were enrolled.
- Data were analysed retrospectively from a prospectively collected database.
- Cumulative probability of tumour progression beyond the Milan criteria at 6, 12, 18, 24 and 36 mos of RF ablation was 6.4, 11.0, 16.1, 21.2, and 44.8% respectively.
- On multivariable analysis, factors independently associated with tumour progression were failure to achieve primary technique effectiveness, α-fetoprotein level >200 ng/ml, and Child-Pugh grade B cirrhosis.
- Failure to achieve primary RF ablation technique effectiveness was associated with tumour location in segment VIII, a cool-down temperature of 70 °C or less, and multiple overlapping ablations.
Related Articles
Invasive papillary carcinoma of the male breast: Report of a rare case and review of the literature
Journal of Cancer Research and Therapeutics, 10/28/09
Relevance Score: 91%
Spread of Squamous Cell Carcinoma From the Thumb to the Small Finger via the Flexor Tendon Sheaths
The Journal of Hand Surgery, 11/16/09
Relevance Score: 90%
Local Biosynthesis of Estrogen in Human Endometrial Carcinoma through Tumor-Stromal Cell Interactions
Clinical Cancer Research, 10/06/09
Relevance Score: 90%
Microscopic polyangitis complicating double carcinoma of the stomach and duodenum: improvement after the resection of these carcinomas
Rheumatology International, 11/16/09
Relevance Score: 89%
H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliary and gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1
Human Pathology, 11/12/09
Relevance Score: 89%
Today in Hepatobiliary/Pancreas...keeping you current
Receive free subspecialty "5-minute updates" via email
An insertion/deletion polymorphism at miRNA-122-binding site in the interleukin-1alpha 3' untranslated region confers risk for hepatocellular carcinoma
Carcinogenesis, 12/16/09
Liver transplantation for primary hepatic leiomyosarcoma: a case report and review of the literatures
Medical Oncology, 12/16/09
Are patients of low socioeconomic status receiving suboptimal management for pancreatic adenocarcinoma
Cancer, 12/15/09