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Caspofungin for the treatment of candidaemia in patients with haematological malignancies
Clinical Microbiology and Infection, 07/01/09

Pagano L et al. - In a study to evaluate the efficacy of caspofungin in neutropenic pts with haematological malignancies (HM) and candidaemia, results suggest that treatment of candidaemia with caspofungin in neutropenic HM was efficacious, as it is in non-haematological subgroups.

Methods

This study was prospectively conducted in 11 haematology divisions over a 2-yr period to evaluate the efficacy of caspofungin in 24 neutropenic pts with haematological malignancies (HM) and candidaemia.

Results

Pts had received chemotherapy for HM and were neutropenic (PNN < 0.5 x 109/L) for a median of 12 days (2–41) before candidaemia.
Pts received caspofungin for a median duration of 12 days, obtaining a favourable overall response of 58%.
At 30 days, 11 pts had died (46%); candidaemia was responsible for mortality in 6 pts (25%).

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A rescue therapy with a combination of caspofungin and liposomal amphotericin B or voriconazole in children with haematological malignancy and refractory invasive fungal infections
Mycoses, 11/12/09 Relevance Score: 80%

Continuous infusion of amphotericin B deoxycholate: an innovative, low-cost strategy in antifungal treatment
Mycoses, 10/29/09 Relevance Score: 80%

Characteristics of Candida albicans Biofilms Grown in a Synthetic Urine Medium
Journal of Clinical Microbiology, 10/08/09 Relevance Score: 80%

Candidiasis: New agents for invasive infections
The Clinical Advisor, 10/06/09 Relevance Score: 77%