Oncology

Your Article Summary

See Latest Articles

Does early prostate-specific antigen doubling time (ePSADT) after radical prostatectomy, calculated using PSA values from the first detectable until the first recurrence value, correlate with standard PSADT? A report from the Shared Equal Access Regional Cancer Hospital Database Group
BJU International, 06/29/09

Teeter AE et al. – Although early PSA doubling time (ePSADT) and PSADT were significantly related, the overall correlation was poor. However, a long ePSADT correlated well with a long PSADT and is thus useful in identifying men at low risk for prostate cancer-specific mortality very early in their biochemical recurrence (BCR).

• Aim was to determine if ePSADT correlated with 'standard' PSADT following BCR
• Spearman's correlation was used to determine the correlation between ePSADT and PSADT among 157 men
• These men underwent RP between 1988 and 2005 and had a calculable ePSADT and PSADT
• ePSADT threshold was examined and their positive and negative predictive values (PPV and NPV, respectively), to predict aggressive recurrences (PSADT of <9 mo)

• ePSADT was significantly, though poorly, correlated with PSADT
• ePSADT more accurately predicted PSADT among men with a long ePSADT
• Of men with an ePSADT of ≥20 or ≥15 mo, the NPV for an aggressive recurrence was 98% and 93%, respectively
• However, among men with an ePSADT of <3 mo, the PPV for aggressive recurrence was only 39%

Related Articles

See all related articles

New Standards Reduce Heparin Potency
JAMA, 11/12/09    Relevance Score: 45%

EHR Firms: Go With Existing Standards
HealthDataManagement, 11/06/09    Relevance Score: 45%

Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma
New England Journal of Medicine, 10/22/09    Relevance Score: 45%

Risperidone dose for schizophrenia
Cochrane Reviews, 10/22/09    Relevance Score: 44%

Is coronary computed tomographic angiography the "gold standard" for coronary artery disease
Journal of Cardiovascular Computed Tomography, 10/16/09    Relevance Score: 44%

Today in Renal/Urologic...keeping you current

Receive free subspecialty "5-minute updates" via email

Efficacy of venlafaxine, medroxyprogesterone acetate, and cyproterone acetate for the treatment of vasomotor hot flushes in men taking gonadotropin-releasing hormone analogues for prostate cancer: A double-blind, randomised trial
The Lancet Oncology - Online First, 12/08/09

Increased prostate-specific membrane antigen expression in LNCaP cells following treatment with bispecific antisense oligonucleotides directed against bcl-2 and EGFR
Medical Oncology, 12/08/09

Frequency of CYP1B1 homozygous genotype 355T/T in prostate cancer families from Poland
European Journal of Cancer Prevention, 12/08/09

 See all of Renal/Urologic