Oncology Medical News about thyroid carcinogenesis

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. Recommendations on the use of 18F-FDG PET in oncology

3. Taxane-based combinations as adjuvant chemotherapy of early breast cancer: a meta-analysis of randomized trials

4. Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer

5. Sentinel node biopsy is important in mastectomy for ductal carcinoma in situ

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Novel non-genomic signaling of thyroid hormone receptors in thyroid carcinogenesis
Molecular and Cellular Endocrinology, 06/29/09

Guigon CJ et al. – Review article highlights the recent advances in understanding of the critical role of novel non-genomic actions of mutations of thyroid hormone receptor (TR) in thyroid carcinogenesis.

Studies so far have shown that the deleterious effects of TRβ mutants in causing resistance to thyroid hormone (RTH) are mediated via dominant negative actions at the transcriptional level
However, novel modes of TRβ mutant actions have been identified from mice study that are beyond nucleus-initiated transcription:
- Direct protein–protein interaction with the PI3K leads to cell proliferation, apoptosis, migration, and metastasis
- Direct interation with PTTG or β-catenin affects their degradation by the proteasomal pathways, thus leading to PTTG and β-catenin aberrant accumulation
- This contributes to genetic instability and constitutively active β-catenin oncogenic signaling to affect cell proliferation and migration
Therefore, the development and progression of thyroid tumors in mice not only involve impaired transcriptional activity but also derailed post-transcriptional mechanisms

<< Previous
One-stage ultrasonographically guided hepatectomy for multiple...

Next >>
Impact of age and gender on the clinicopathological...