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Novel non-genomic signaling of thyroid hormone receptors in thyroid carcinogenesis
Molecular and Cellular Endocrinology, 06/29/09
Guigon CJ et al. – Review article highlights the recent advances in understanding of the critical role of novel non-genomic actions of mutations of thyroid hormone receptor (TR) in thyroid carcinogenesis.
- Studies so far have shown that the deleterious effects of TRβ mutants in causing resistance to thyroid hormone (RTH) are mediated via dominant negative actions at the transcriptional level
- However, novel modes of TRβ mutant actions have been identified from mice study that are beyond nucleus-initiated transcription:
- Direct protein–protein interaction with the PI3K leads to cell proliferation, apoptosis, migration, and metastasis
- Direct interation with PTTG or β-catenin affects their degradation by the proteasomal pathways, thus leading to PTTG and β-catenin aberrant accumulation
- This contributes to genetic instability and constitutively active β-catenin oncogenic signaling to affect cell proliferation and migration
- Therefore, the development and progression of thyroid tumors in mice not only involve impaired transcriptional activity but also derailed post-transcriptional mechanisms
Today in Basic Science/Genetics...keeping you current
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Serum calcium levels are elevated among women with untreated postmenopausal breast cancer
Cancer Causes and Control, 11/03/09
Prognostic and predictive value of HER2 extracellular domain in metastatic breast cancer treated with lapatinib and paclitaxel in a randomized phase III study
Journal of Clinical Oncology, 10/29/09
Contralateral breast cancer risk in BRCA1 and BRCA2 mutation carriers
Journal of Clinical Oncology, 10/29/09
Today in Endocrine Oncology...keeping you current
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Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer
Thyroid, 10/30/09
Thyroid lymphoma and airway obstruction – is there a rationale for surgical management?
International Journal of Clinical Practice, 10/19/09
Thyroid Cancer in Systemic Lupus Erythematosus: A Case-Control Study
Journal of Clinical Endocrinology and Metabolism, 11/12/09
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