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Surface RANKL of toll-like receptor 4-stimulated human neutrophils activates osteoclastic bone resorption
Blood, 06/24/09
Chakravarti A et al. - Activation of neutrophil membrane-bound RANKL was linked to tyrosine phosphorylation of Src-homology domain-containing cytosolic phosphatase 1 with concomitant downregulation of cytokine production. The demonstration of these novel functions of neutrophils highlights their potential role in osteoimmunology and in therapeutics of inflammatory bone disease.
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Today in Basic Science/Genetics...keeping you current
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