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See Latest ArticlesExpression of autotaxin and acylglycerol kinase in prostate cancer: association with cancer development and progression
Cancer Science, 06/24/09
Nouh MAAM et al. - In a trial to analyze expression levels of lysophosphatidic acid (LPA)-producing enzymes, autotaxin (ATX) and acylglycerol kinase (AGK), in prostate cancer (PC) with relevance to clinicopathological parameters, it was concluded that LPA-producing enzymes (ATX and AGK) were frequently expressed in PC cells and precancerous high-grade intra-epithelial neoplasia (HG-PIN). In particular, high expression levels of ATX were associated with both malignant potentials and poor outcomes.
Methods- Real-time RT-PCR and western blotting were performed for ATX and AGK in non-neoplastic prostate cells (PrECs and PrSCs) and PC cell-lines (DU-145, PC-3, LNCaP, and AILNCaP).
- Immunohistochemical analyses were conducted in tissue specimens of 132 localized PC pts who underwent radical prostatectomy between 2001 and 2007.
- Both enzymes were negatively expressed in PrECs and PrSCs at mRNA and protein levels.
- ATX expression was higher than AGK in AILNCaP, DU-145, and PC-3 cell-lines, while AGK was mainly expressed in LNCaP cells.
- Immunohistochemically, ATX and AGK expressions were negative in non-neoplastic epithelia, while both were weakly expressed in the majority of HG-PIN.
- In cancer foci, ATX and AGK expressions were strong in 49% and 62%, weak in 40% and 32%, and negative in 11% and 6%, respectively.
- Expressions of both enzymes were significantly correlated with primary Gleason grade of cancer foci and capsular invasion.
- ATX expression was significantly correlated with probability of prostate specific antigen (PSA)-failure after surgery.
Mohammed A.M. Nouh, 06/24/09
| In our study, we found that LPA and its producing enzymes' expression are closely linked to the histo-pathological pattern in Prostate cancer. The major differences between ATX and AGK expression patterns in prostate cancer may reflect a possible specified role of each enzyme in LPA production during different stages of cancer development and progression. Also, these findings show that both enzymes could be considered in the future as molecularly-targeted therapy in management of prostate cancer. |
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