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Thyroid tumours of uncertain malignant potential: frequency and diagnostic reproducibility
Virchows Archiv, 06/24/09

Hofman V et al. - In a trial to investigate the frequency of thyroid tumours of uncertain malignant potential (TT-UMP) diagnosed in a single institution, observer variation among 4 pathologists, and whether immunohistochemical and molecular genetic profiling of TT-UMP provide additional information concerning such lesions, it was found that the frequency of TT-UMP is low in the institution. Diagnostic reproducibility is within the same range as other published data on follicular-patterned thyroid tumours. The ancillary methods have a low impact on aiding diagnosis of such lesions.

• A series of 31 diagnosed TT-UMP (2.9%) out of 1078 consecutive thyroidectomies were analysed.

• It comprised 15 follicular thyroid tumours of UMP (FT-UMP) and 16 well-differentiated tumours of UMP (WDT-UMP).
• Observer concordance was 70% for all TT-UMP.
• >50% of FT-UMP expressed galectin-3 and CK19, whereas >50% of WDT-UMP expressed HBME-1.
• 5 cases of TT-UMP showed N-RAS mutations, while 1 showed H-RAS mutation and another PAX8/PPARγ rearrangement.

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