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Diffusion-weighted imaging of mucinous carcinoma of the breast
American Journal of Roentgenology, 06/29/09

Woodhams R et al. - Study demonstrates that mucinous carcinoma can be clearly differentiated from other breast tumors on the basis of apparent diffusion coefficient (ADC). The low and high signal intensity of mucinous carcinoma on diffusion-weighted images reflects distinct features.

Methods

Objectives of this study were to:
- Compare ADC of mucinous carcinoma of the breast with that of other breast tumors, and
- Analyze correlations between signal intensity on diffusion-weighted images and the histologic features of mucinous carcinoma
276 pts with 277 lesions, including:
- 15 mucinous carcinomas (13 pure type, 2 mixed type)
- 204 other malignant tumors, and
- 58 benign lesions
  were examined with 1.5-T MRI at b values of 0 and 1,500 s/mm²
Correlations between cellularity and ADC, homogeneity of signal intensity on diffusion-weighted images, and histopathologic findings were analyzed

Results

Mean ADC of mucinous carcinoma was higher than that of benign lesions and other malignant tumors
ADC of pure type mucinous carcinoma was higher than that of mixed type mucinous carcinoma and other histologic types
Correlation between mean cellularity and ADC of mucinous carcinoma was significant
Homogeneity of signal intensity on diffusion-weighted images correlated with the homogeneity of histologic structures

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