Oncology Medical News about TGF1-Dependent Myofibroblast

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Modulation of TGF1-Dependent Myofibroblast Differentiation by Hyaluronan
American Journal of Pathology, 06/23/09

Webber J et al. - The data highlight a role for endogenous hyaluronan in the mediation of myofibroblastic differentiation. While hyaluronan synthesis was both essential and necessary for differentiation, exogenously provided hyaluronan antagonized differentiation, underscoring a pathological role for hyaluronan in such cell fate processes.

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NAD(P)H Oxidase Mediates TGF-[beta]1–Induced Activation of Kidney Myofibroblasts
Journal of the American Society of Nephrology, 11/20/09 Relevance Score: 43%%

Monocyte chemoattractant protein-1 (MCP-1)/CCL2 secreted by hepatic myofibroblasts promotes migration and invasion of human hepatoma cells
International Journal of Cancer, 11/10/09 Relevance Score: 43%%

TGF-beta-induced interleukin-6 participates in transdifferentiation of human Tenon's fibroblasts to myofibroblasts
Molecular Vision, 10/26/09 Relevance Score: 42%%

Tumor-host histopathologic variables, stromal myofibroblasts and risk score, are significantly associated with recurrent disease in tongue cancer
Cancer Science, 10/08/09 Relevance Score: 42%%

The Sonic Hedgehog pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofibroblasts
Oncogene, 10/01/09 Relevance Score: 42%%