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Endothelin-Converting Enzyme-2 Is Increased in Alzheimer's Disease and Up-Regulated by A beta
American Journal of Pathology, 06/23/09

Palmer JC et al. - ECE-2 expression is up-regulated, perhaps to minimize A beta accumulation, but this may also be a mechanism through which endothelin-1 production is increased and cerebral blood flow is reduced in AD. The findings suggest that endothelin-1 receptor antagonists, already licensed for treating other diseases, could be of benefit in AD therapies.

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