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Predictors of avascular necrosis of bone in long-term survivors of hematopoietic cell transplantation
Cancer, 07/01/09
Campbell S et al. - For allogeneic transplant recipients, male sex; presence of chronic graft-versus-host disease; and exposure to CSA, FK506, prednisone, and MMF rendered patients at increased risk, especially in patients with a history of exposure to >=3 drugs. Future studies examining the pathogenetic mechanism underlying AVN should help develop targeted interventions to prevent this chronic debilitating condition.
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