Your Article Summary
See Latest ArticlesHealth-related quality of life as a survival predictor for patients with localized head and neck cancer treated with radiation therapy
Journal of Clinical Oncology, 06/22/09
Meyer F et al. - Findings indicate that both baseline physical functioning (PF) and PF change provide added prognostic value for overall survival (OS) beyond established predictors in patients with head and neck cancer (HNC). Assessing health-related quality of life (HRQOL) could help better predict survival of cancer patients.
Methods- Aim was to assess the added prognostic value for OS of baseline HRQOL and of early changes in HRQOL among pts with localized HNC treated with radiation therapy
- 540 pts completed 2 HRQOL instruments before radiation therapy:
- European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) and
- Head and Neck Radiotherapy Questionnaire
- 6 mo after the end of radiation therapy, 497 trial participants again completed the 2 HRQOL instruments
- During the f/u, 179 deaths were observed
- Multivariate Cox proportional hazards models were used to test whether HRQOL variables, baseline and change, provided additional prognostic value
- Baseline EORTC QLQ-C30 PF score was an independent predictor of OS
- Hazard ratio (HR) associated with a 10-point increment in baseline PF was 0.87
- Multivariate models: change in HRQOL was significantly associated with OS for most HRQOL dimensions
- Among these, PF change was the strongest predictor
- Magnitude of the association between PF change and survival decreased over time
- At 1 yr, the HR associated with a positive PF change of 10 points was 0.75
- After PF is taken into account, no other HRQOL variable was associated with survival
Related Articles
Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk
International Journal of Epidemiology, 10/08/09
Relevance Score: 84%
Planned neck dissection following primary chemoradiation for advanced-stage head and neck cancer
Otolaryngology Head and Neck Surgery, 10/13/09
Relevance Score: 83%
Extracts from The Cochrane Library: Erythropoietin as an adjuvant treatment with (chemo) radiation therapy for head and neck cancer
Otolaryngology Head and Neck Surgery, 10/12/09
Relevance Score: 83%
Clinical Features and Short-Term Outcome of Critically Ill Patients With Head and Neck Cancer in the Medical Intensive Care Unit
American Journal of Clinical Oncology, 10/07/09
Relevance Score: 83%
Sheddase Activity of Tumor Necrosis Factor-alpha Converting Enzyme Is Increased and Prognostically Valuable in Head and Neck Cancer
Cancer Epidemiology, Biomarkers & Prevention, 10/27/09
Relevance Score: 82%
Today in Diagnostics/Radiology...keeping you current
Receive free subspecialty "5-minute updates" via email
Failure to Diagnose and Delayed Diagnosis of Cancer
The Journal of the American Dental Association , 12/07/09
Malignant granular cell tumor: case report with a novel karyotype and review of the literature
Annals of Diagnostic Pathology, 12/04/09
Concurrent diagnoses of Hodgkin lymphoma and biclonal myeloma in the bone marrow
Annals of Diagnostic Pathology, 12/04/09
Today in Head and Neck...keeping you current
Receive free subspecialty "5-minute updates" via email
Failure to Diagnose and Delayed Diagnosis of Cancer
The Journal of the American Dental Association , 12/07/09
Prospective study of daily low-dose nedaplatin and continuous 5-fluorouracil infusion combined with radiation for the treatment of esophageal squamous cell carcinoma
BMC Cancer, 12/04/09
Predictors of Competing Mortality in Advanced Head and Neck Cancer
Journal of Clinical Oncology, 12/04/09